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Prolotherapy for the Patients with Chronic Musculoskeletal Pain: Systematic Review and Meta-analysis by Geonhyeong Bae; Suyeon Kim; Sangseok Lee; Woo Yong Lee; Yunhee Lim is a Medicine article available to read on EtoBox.

What is Prolotherapy for the Patients with Chronic Musculoskeletal Pain: Systematic Review and Meta-analysis about?

## Background Prolotherapy, which stimulates the healing of loosened ligaments and tendons, is a cost-effective and safe treatment modality for chronic musculoskeletal pain. Its benefits may be affected by injection protocols, comparative regimens, and evaluation scales. The aim of this study was to determine the effectiveness of dextrose prolotherapy as a long-term treatment for chronic musculoskeletal pain. ## Methods Medline, Embase, Cochrane Central, KoreaMed, and KMbase databases were searched for studies published up to March 2019. We included randomized controlled trials which compared the effect of dextrose prolotherapy with that of other therapies such as exercise, saline, platelet-rich plasma, and steroid injection. The primary outcome was pain score change during daily life. ## Results Ten studies involving 750 participants were included in the final analysis. Pain scores from 6 months to 1 year after dextrose prolotherapy were significantly reduced compared to saline injection (standardized mean difference [SMD] –0.44; 95% confidence interval [CI] –0.76 to –0.11, P = 0.008) and exercise (SMD –0.42; 95% CI –0.77 to –0.07, P = 0.02). Prolotherapy yielded results similar t

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Author

Geonhyeong Bae; Suyeon Kim; Sangseok Lee; Woo Yong Lee; Yunhee Lim

Publisher

The Editorial Office of Anesthesia and Pain Medicine

Published

2020

Language

EN

Field

Medicine (Health Sciences)