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Uptitrating Treatment After Heart Failure Hospitalization Across the Spectrum of Left Ventricular Ejection Fraction by Matteo Pagnesi; Marco Metra; Alain Cohen-Solal; Christopher Edwards; Marianna Adamo; Daniela Tomasoni; Carolyn S.P. Lam; Ovidiu Chioncel; Rafael Diaz; Gerasimos Filippatos; Piotr Ponikowski; Karen Sliwa; Adriaan A. Voors; Antoine Kimmoun; Maria Novosadova; Koji Takagi; Marianela Barros; Albertino Damasceno; Hadiza Saidu; Etienne Gayat; Peter S. Pang; Jelena Celutkiene; Gad Cotter; Alexandre Mebazaa; Beth Davison is a Medicine article available to read on EtoBox.
What is Uptitrating Treatment After Heart Failure Hospitalization Across the Spectrum of Left Ventricular Ejection Fraction about?
Background Acute heart failure (AHF) is associated with a poor prognosis regardless of left ventricular ejection fraction (LVEF). STRONG-HF showed the efficacy and safety of a strategy of rapid uptitration of oral treatment for heart failure (HF) and close follow-up (high-intensity care), compared with usual care, in patients recently hospitalized for AHF and enrolled independently from their LVEF. Objectives In this study, we sought to assess the impact of baseline LVEF on the effects of high-intensity care vs usual care in STRONG-HF. Methods The STRONG-HF trial enrolled patients hospitalized for AHF with any LVEF and not treated with full doses of renin-angiotensin inhibitors, beta-blockers, and mineralocorticoid receptor antagonists. High-intensity care with uptitration of oral medications was performed independently from LVEF. The primary endpoint was the composite of HF rehospitalization or all-cause death at day 180. Results Among the 1,078 patients randomized, 731 (68%) had LVEF ≤40% and 347 (32%) had LVEF >40%. The treatment benefit of high-intensity care vs usual care on the primary endpoint was consistent across the whole LVEF spectrum (interaction P with LVEF as a contin
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- Author
- Matteo Pagnesi; Marco Metra; Alain Cohen-Solal; Christopher Edwards; Marianna Adamo; Daniela Tomasoni; Carolyn S.P. Lam; Ovidiu Chioncel; Rafael Diaz; Gerasimos Filippatos; Piotr Ponikowski; Karen Sliwa; Adriaan A. Voors; Antoine Kimmoun; Maria Novosadova; Koji Takagi; Marianela Barros; Albertino Damasceno; Hadiza Saidu; Etienne Gayat; Peter S. Pang; Jelena Celutkiene; Gad Cotter; Alexandre Mebazaa; Beth Davison
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)