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This document provides an overview of the chemistry involved in synthesizing fluorodeoxyglucose ([18F]FDG), a radiopharmaceutical used in positron emission tomography (PET) imaging. It discusses two main routes for synthesizing [18F]FDG - electrophilic fluorination and nucleophilic substitution. Electrophilic fluorination involves introducing radioactive fluorine-18 ([18F]) produced in gaseous form into a triacetylglucal precursor, while nucleophilic substitution uses [18F] fluoride and a tetraacetylmannose

Author

Patricio Alfaro

Language

EN