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Could Targeting NPM1c+ Misfolding Be A Promising Strategy For Combating Acute Myeloid Leukemia? by Reinaldi octa is a document available to read on EtoBox.
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This review discusses the potential of targeting misfolded nucleophosmin 1 (NPM1) mutations, particularly NPM1c+, as a therapeutic strategy for acute myeloid leukemia (AML). NPM1 mutations are prevalent in approximately 30-35% of adult AML cases and lead to aberrant cellular localization and function, which can be exploited for treatment. The authors propose novel strategies that involve agents capable of enhancing amyloid aggregation to selectively induce cytotoxicity in leukemic cells harboring NPM1c+ mut
- Author
- Reinaldi octa
- Language
- EN