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PIII-25The functional consequence of the Glu298Asp polymorphism of the eNOS gene in humans by LANG, C; CHAN, S; GODFREY, V; BUTLER, R; CASSIDY, A; FARDON, T; CHOY, A; STRUTHERS, A is a scholarly article available to read on EtoBox.

What is PIII-25The functional consequence of the Glu298Asp polymorphism of the eNOS gene in humans about?

BACKGROUND: The Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene has been linked to cardiovascular disease. However, the functional consequences of this polymorphism have not been fully defined. Our aim was to investigate if this polymorphism is functionally relevant in healthy humans by having an effect on endothelial-dependent vasodilatation. METHODS: Endothelial function was assessed in 68 normal volunteers (aged 18-44y) by bilateral forearm venous occlusion plethysmography with intra-arterial infusions of increasing doses of acetylcholine for endothelial dependent vasodilatation, sodium nitroprusside and verapamil for endothelial independent vasodilatation. Blood was genotyped by polymerase chain reaction and BanII digestion. RESULTS: There were 3 genotypes: homozygous for the Glu298 variant (GG), homozygous for the Asp298 variant (TT) and heterozygous (GT). The TT genotype's vasodilatory response to the endothelial-dependent vasodilator acetylcholine was lower than the GG variant (pϭ0.04) and GT variant (pϭ0.08) (Fig) . No differences were found between the GG and GT groups (pϭNS). There was also no effect of eNOS genotype on the response to the endo

Author

LANG, C; CHAN, S; GODFREY, V; BUTLER, R; CASSIDY, A; FARDON, T; CHOY, A; STRUTHERS, A

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

2006

Language

EN