Can I read Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials on EtoBox?

Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials by Thomas Creasey; Emilio Barretta; Sarra L. Ryan; Ellie Butler; Amy A. Kirkwood; Daniel Leongamornlert; Elli Papaemmanuil; Pip Patrick; Laura Clifton-Hadley; Bela Patel; Tobias Menne; Andrew K. McMillan; Christine J. Harrison; Clare J. Rowntree; Nick Morley; David I. Marks; Adele K. Fielding; Anthony V. Moorman is a Medicine article available to read on EtoBox.

What is Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials about?

Despite being predominantly a childhood disease, the incidence of acute lymphoblastic leukemia (ALL) has a second peak in adults aged 60 years and over. These older adults fare extremely poorly with existing treatment strategies and very few studies have undertaken a comprehensive genetic and genomic characterization to improve prognosis in this age group. We performed cytogenetic, single nucleotide polymorphism (SNP) array and next-generation sequencing (NGS) analyses on samples from 210 patients aged ≥60 years from the UKALL14 and UKALL60+ clinical trials. __BCR-ABL1__-positive disease was present in 26% (55/210) of patients, followed by low hypodiploidy/near triploidy in 13% (28/210). Cytogenetically cryptic rearrangements in __CRLF2__, __ZNF384__ and __MEF2D__ were detected in 5%, 1% and <1% of patients, respectively. Copy number abnormalities were common and deletions in ALL driver genes were seen in 77% of cases. __IKZF1__ deletion was present in 51% (40/78) of samples tested and the __IKZF1^plus^__ profile was identified in over a third (28/77) of cases of B-cell precursor ALL. The genetic good-risk abnormalities high hyperdiploidy (n=2), __ETV6-RUNX1__ (no cases) and __ERG_

Who reads Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials?

Author

Thomas Creasey; Emilio Barretta; Sarra L. Ryan; Ellie Butler; Amy A. Kirkwood; Daniel Leongamornlert; Elli Papaemmanuil; Pip Patrick; Laura Clifton-Hadley; Bela Patel; Tobias Menne; Andrew K. McMillan; Christine J. Harrison; Clare J. Rowntree; Nick Morley; David I. Marks; Adele K. Fielding; Anthony V. Moorman

Publisher

Ferrata Storti Foundation (Haematologica)

Published

2021

Language

EN

Field

Medicine (Health Sciences)