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Can I read Marginative Delivery-Mediated Extracellular Leakiness and T Cell Infiltration in Lung Metastasis by a Biomimetic Nanoraspberry on EtoBox?
Marginative Delivery-Mediated Extracellular Leakiness and T Cell Infiltration in Lung Metastasis by a Biomimetic Nanoraspberry by Shen, Wei-Ting; Hsu, Ru-Siou; Fang, Jen-Hung; Hu, Pei-Fen; Chiang, Chi-Shiun; Hu, Shang-Hsiu is a Engineering article available to read on EtoBox.
What is Marginative Delivery-Mediated Extracellular Leakiness and T Cell Infiltration in Lung Metastasis by a Biomimetic Nanoraspberry about?
T lymphocytes infiltrate the most devastating metastatic tumors for immunotherapy, allowing the potential for tumor metastasis suppression. However, tumor heterogeneity often restricts the infiltration of immune cells and possesses immune privilege that leads to protection from the immune attack, especially for invading metastatic clusters. Here, an exosome-camouflaged nanoraspberry (RB@Exo) doubling as a metastases-targeting agent and T cell-infiltration inducer that delivers an anticancer drug and energy is reported. The RB@Exo integrated an exosome-derived margination effect, and density-mediated nanoparticle-induced extracellular leakiness (nanoEL) exhibited more than a 70% colocalization of the RB@Exo to metastatic tumors in the lung . The release of cancer cell-cell interactions at the metastasis via nanoEL also elicited the 10-fold infiltration of T lymphocytes. The synergy of the T cell infiltration and photolytic effects transported by the RB@Exo deep into the metastatic tumors effectively inhibited the tumor in 60 days when treated with a single alternating magnetic field (AMF).
Who reads Marginative Delivery-Mediated Extracellular Leakiness and T Cell Infiltration in Lung Metastasis by a Biomimetic Nanoraspberry?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Shen, Wei-Ting; Hsu, Ru-Siou; Fang, Jen-Hung; Hu, Pei-Fen; Chiang, Chi-Shiun; Hu, Shang-Hsiu
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 1530-6984)
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)