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IL-8 and TNF-α from peripheral neutrophils and acute-phase proteins in periodontitis : Effect of cigarette smoking: a pilot study by M. Fredriksson; K. Bergström; B. Åsman is a scholarly article available to read on EtoBox.

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## Abstract **Objective:** In other studies, we have found deviant functions in peripheral neutrophils in periodontitis. The aim here was to study (1) the release of cytokines, IL‐8 and TNFα, from neutrophils in 15 treated periodontitis patients and pair‐matched controls as well as (2) the effects of cigarette smoking. **Material and methods:** Cytokines released in the incubation medium from un‐stimulated and Fcγ‐R‐stimulated neutrophils and some acute‐phase reactants were measured with ELISA. **Results:** Non‐smoking patients had trends for lower TNFα release compared to non‐smoking controls, while corresponding trends were rather similar for Il‐8. Smoking had a moderate but inconsistent effect on the release of both cytokines. However, in patients, the ratio between stimulated/un‐stimulated release of Il‐8 was significantly lowered by smoking (__p__<0.03). The parameters of inflammation in plasma differed only slightly between patients and controls, indicating that periodontal disease in a quiet phase has a negligible systemic effect with the possible exception for a higher IL‐8 level. In contrast, smoking had significant systemic effect on the neutrophil count and IgG levels. *

Author

M. Fredriksson; K. Bergström; B. Åsman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6979)

Published

2002

Language

EN