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Population Pharmacokinetics of Doxorubicin, Etoposide and Ifosfamide in Small Cell Lung Cancer Patients: Results of a Multicentre Study by Gilles Freyer; Brigitte Tranchand; Blandine Ligneau,; Claude Ardiet; Pierre‐Jean Souquet,; Isabelle Court‐Fortune,; Robert Riou,; Paul Rebattu,; Jean‐Pierre Boissel; Véronique Trillet‐Lenoir; Pascal Girard is a Medicine article available to read on EtoBox.

What is Population Pharmacokinetics of Doxorubicin, Etoposide and Ifosfamide in Small Cell Lung Cancer Patients: Results of a Multicentre Study about?

**__Aims__** To determine the population pharmacokinetic (PK) parameters of doxorubicin (Dox), etoposide (Eto) and ifosfamide (Ifo) in small cell lung cancer (SCLC) patients, to assess the potential relationship between those parameters and to estimate the impact of individual morphological and biological covariates on patients' PK parameters. **__Methods__** Twenty‐four patients with either SCLC limited to the thorax or extensive SCLC entered the study. All but one received at least two 3 day courses of the standard AVI (Dox 50 mg m^−2^ day 1, Eto 120 mg m^−2^ day 1,2,3, Ifo 2000 mg m^−2^ day 1,2) regimen. Individual blood samples were collected during each course and data on 47 courses were available. Data were analysed with the NONMEM program. Dox, Eto and Ifo plasma concentrations were studied with multicompartment (3, 2 and 2, respectively) models. Inter‐individual and interoccasion (course‐to‐course) variabilities were estimated. The influence of individual covariates (age, sex, stage of the disease, weight, height, body‐surface area, serum creatinine, total protein, LDH, ASAT, ALAT, alkaline phosphatase, gamma‐GT, bilirubin) on PK parameters was also assessed. Correlations b

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Author

Gilles Freyer; Brigitte Tranchand; Blandine Ligneau,; Claude Ardiet; Pierre‐Jean Souquet,; Isabelle Court‐Fortune,; Robert Riou,; Paul Rebattu,; Jean‐Pierre Boissel; Véronique Trillet‐Lenoir; Pascal Girard

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

2000

Language

EN

Field

Medicine (Health Sciences)