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Systematic interpretation of cyclic nucleotide binding studies using KinetXBase by Sonja Schweinsberg; Daniela Moll; Nicole C. G. Burghardt; Claudia Hahnefeld; Frank Schwede; Bastian Zimmermann; Stephan Drewianka; Lars Werner; Frank Kleinjung; Hans‐Gottfried Genieser; Johannes Schuchhardt; Friedrich W. Herberg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Functional proteomics aims to describe cellular protein networks in depth based on the quantification of molecular interactions. In order to study the interaction of adenosine‐3′,5′‐cyclic monophosphate (cAMP), a general second messenger involved in several intracellular signalling networks, with one of its respective target proteins, the regulatory (R) subunit of cAMP dependent protein kinase (PKA), a number of different methods was employed. These include fluorescence polarisation (FP), isothermal titration calorimetry (ITC), surface plasmon resonance (SPR), amplified luminescence proximity homogeneous assay (ALPHA‐screen), radioligand binding or activity‐based assays. Kinetic, thermodynamic and equilibrium binding data of a variety of cAMP derivatives to several cAMP binding domains were integrated in a single database system, we called KinetXBase, allowing for very distinct data formats. KinetXBase is a practical data handling system for molecular interaction data of any kind, providing a synopsis of data derived from different technologies. This supports ongoing efforts in the bioinformatics community to devise formal concepts for a unified representation of intera
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- Author
- Sonja Schweinsberg; Daniela Moll; Nicole C. G. Burghardt; Claudia Hahnefeld; Frank Schwede; Bastian Zimmermann; Stephan Drewianka; Lars Werner; Frank Kleinjung; Hans‐Gottfried Genieser; Johannes Schuchhardt; Friedrich W. Herberg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)