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Chronic myeloid leukemia (CML) is a chronic myeloproliferative neoplasm originating from a pluripotent hematopoietic stem cell. It is characterized by the predominant proliferation of granulocytic cells and the presence of the Philadelphia chromosome, a translocation between chromosomes 9 and 22. CML typically presents insidiously with symptoms related to hypermetabolism, splenomegaly, anemia, or bleeding. The disease progresses through chronic, accelerated, and blast crisis phases. Diagnosis is confirmed

Author

Razib Hasan

Language

EN