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The M3 muscarinic receptor (M3R) in the bladder is essential for urination by mediating detrusor muscle contraction through a G-protein coupled signaling pathway. Acetylcholine release activates the M3R, leading to increased intracellular calcium and myosin-actin interactions that result in muscle contraction. Additionally, the Rho-kinase pathway sustains muscle contraction for effective bladder emptying.

Author

whatsupmygang27120

Language

EN