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The Impact of Fetal Sex on Risk Factors for Gestational Diabetes and Related Adverse Pregnancy Outcomes by Giuseppe Seghieri; Graziano Di Cianni; Elisa Gualdani; Alessandra De Bellis; Flavia Franconi; Paolo Francesconi is a Medicine article available to read on EtoBox.
What is The Impact of Fetal Sex on Risk Factors for Gestational Diabetes and Related Adverse Pregnancy Outcomes about?
## Aims: To investigate whether fetal sex affects the impact of classical gdm risk factors on the diagnosis of gestational diabetes (gdm) as well as on related adverse pregnancy outcomes. ## Methods: This retrospective observational study concerned 206,917 singleton live births born to 170,126 women aged 15-45 over the years 2010-2018 in tuscany, italy. gdm was identified by administrative data-sources in 21,613 pregnancies (10.5%) by assessing, through multiple logistic models, whether fetal sex modified the risk of gdm driven by maternal risk factors, and whether it modified the risk of adverse outcomes such as prematurity (birth ≤ 37th gestational week), large for gestational age (lga), unplanned caesarean sections, or 5-min-apgar-index ≤ 7 in pregnancies with gdm. ## Results: Gdm was diagnosed in 21,613 pregnancies (10.5%). male fetal sex predicted a higher adjusted risk of gdm: or = 1.05(95% ci: 1.01-1.07); p < 0.0009. in pregnancies with female sex, pre-pregnancy obesity amplified the risk of gdm: or = 1.09(95% ci: 1.01-1.19); p = 0.04. in pregnancies with gdm, carrying a female fetus increased the risk of lga associated with pregestational obesity or = 1.45(95% ci: 1.15-1.8
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- Author
- Giuseppe Seghieri; Graziano Di Cianni; Elisa Gualdani; Alessandra De Bellis; Flavia Franconi; Paolo Francesconi
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)