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This research demonstrates that mepyramine effectively targets mutant Nav1.7 channels to alleviate pain and erythema in patients with primary erythromelalgia (PEM), a condition caused by gain-of-function mutations in the SCN9A gene. The study shows that mepyramine provides significant pain relief in PEM patients who are unresponsive to conventional treatments, indicating its potential as a new therapeutic approach. The findings suggest that mepyramine could be a promising topical analgesic and anti-inflamma

Author

Camille 1

Language

EN