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Can I read Pharmacokinetics of Oral Amlodipine Orotate in Vagotomized Dogs on EtoBox?
Pharmacokinetics of Oral Amlodipine Orotate in Vagotomized Dogs by Hyun H. Kwak; Jong O. Kim; Han K. Chung; Seul M. Choi; Jung H. Kim; Jong W. Kwon; Moohi Yoo; Joo H. Lee; Myung G. Lee is a Medicine article available to read on EtoBox.
What is Pharmacokinetics of Oral Amlodipine Orotate in Vagotomized Dogs about?
It was reported that gastric motility was delayed and gastric acid secretion was reduced in vagotomized dogs which mimics a low gastric acidity in humans. A delay in gastric motility causes long residence of amlodipine in the stomach. More unionized fractions of amlodipine could exist in less acidic conditions of gastrointestinal fluids, since amlodipine is a weak basic drug with pKa of 8.7. Hence, gastrointestinal absorption of amlodipine is expected to be enhanced and the time to reach a peak plasma concentration of amlodipine (T max ) is faster in vagotomized dogs. This was proven after oral administration of an amlodipine orotate tablet at a dose of 5 mg as amlodipine in vagotomized dogs. For example, in vagotomized dogs, the total area under the plasma concentration-time curve from time zero to the last measured time, 48 h, in plasma (AUC 0-48 h ) was significantly greater (725 versus 348 ng h/ml) and T max was significantly shorter (1.50 versus 5.00 h) than those in dogs without vagotomy.
Who reads Pharmacokinetics of Oral Amlodipine Orotate in Vagotomized Dogs?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hyun H. Kwak; Jong O. Kim; Han K. Chung; Seul M. Choi; Jung H. Kim; Jong W. Kwon; Moohi Yoo; Joo H. Lee; Myung G. Lee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)