Can I read In vivo biological performance of a novel highly bioactive glass‐ceramic (Biosilicate®): A biomechanical and histomorphometric study in rat tibial defects on EtoBox?
In vivo biological performance of a novel highly bioactive glass‐ceramic (Biosilicate®): A biomechanical and histomorphometric study in rat tibial defects by Renata N. Granito; Ana Claudia Rennó; Christian Ravagnani; Paulo S. Bossini; Daniel Mochiuti; Vanda Jorgetti; Patricia Driusso; Oscar Peitl; Edgar D. Zanotto; Nivaldo A. Parizotto; Jorge Oishi is a Medicine article available to read on EtoBox.
What is In vivo biological performance of a novel highly bioactive glass‐ceramic (Biosilicate®): A biomechanical and histomorphometric study in rat tibial defects about?
## Abstract This study aimed to investigate bone responses to a novel bioactive fully crystallized glass‐ceramic of the quaternary system P~2~O~5~‐Na~2~O‐CaO‐SiO~2~ (Biosilicate®). Although a previous study demonstrated positive effects of Biosilicate® on in vitro bone‐like matrix formation, its __in vivo__ effect was not studied yet. Male Wistar rats (__n__ = 40) with tibial defects were used. Four experimental groups were designed to compare this novel biomaterial with a gold standard bioactive material (Bioglass® 45S5), unfilled defects and intact controls. A three‐point bending test was performed 20 days after the surgical procedure, as well as the histomorphometric analysis in two regions of interest: cortical bone and medullary canal where the particulate biomaterial was implanted. The biomechanical test revealed a significant increase in the maximum load at failure and stiffness in the Biosilicate® group (vs. control defects), whose values were similar to uninjured bones. There were no differences in the cortical bone parameters in groups with bone defects, but a great deal of woven bone was present surrounding Biosilicate® and Bioglass® 45S5 particulate. Although both bioac
Who reads In vivo biological performance of a novel highly bioactive glass‐ceramic (Biosilicate®): A biomechanical and histomorphometric study in rat tibial defects?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Renata N. Granito; Ana Claudia Rennó; Christian Ravagnani; Paulo S. Bossini; Daniel Mochiuti; Vanda Jorgetti; Patricia Driusso; Oscar Peitl; Edgar D. Zanotto; Nivaldo A. Parizotto; Jorge Oishi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)