About this Medicine article

Genital Abnormalities, Hormonal Contraception, and Human Immunodeficiency Virus Transmission Risk in Rwandan Serodifferent Couples by Kristin M Wall; Etienne Karita; Julien Nyombayire; Rosine Ingabire; Jeannine Mukamuyango; Rachel Parker; Ilene Brill; Matt Price; Lisa B Haddad; Amanda Tichacek; Eric Hunter; Susan Allen is a Medicine article available to read on EtoBox.

## Abstract ## Background We explored the role of genital abnormalities and hormonal contraception in human immunodeficiency virus (HIV) transmission among heterosexual serodifferent couples in Rwanda. ## Methods From 2002 to 2011, HIV-serodifferent couples who were not using antiretroviral treatment were followed up, and sociodemographic and clinical data were collected, family planning provided, and HIV-negative partners retested. Couples were assessed for genital ulcers; nonulcerative genital sexually transmitted infection (STIs), including gonorrhea, chlamydia, and trichomoniasis; and non-STI vaginal infections, including bacterial vaginosis and candida. Multivariable models evaluated associations between covariates and HIV transmission genetically linked to the index partner. ## Results Among 877 couples in which the man was HIV positive, 37 linked transmissions occurred. Factors associated with women’s HIV acquisition included genital ulceration in the female partner (adjusted hazard ratio, 14.1) and nonulcerative STI in the male partner (8.6). Among 955 couples in which the woman was HIV positive, 46 linked transmissions occurred. Factors associated with HIV acquisition in m

Author

Kristin M Wall; Etienne Karita; Julien Nyombayire; Rosine Ingabire; Jeannine Mukamuyango; Rachel Parker; Ilene Brill; Matt Price; Lisa B Haddad; Amanda Tichacek; Eric Hunter; Susan Allen

Publisher

Oxford University Press (OUP)

Published

2021

Language

EN

Field

Medicine (Health Sciences)