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Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis by Xuebing Wang; Xiao Li; Xuefang Wang; Ling Chen; Erjuan Ning; Yi Fan; Hao Wang; Tong Chen; Wei Wang is a scholarly article available to read on EtoBox.

What is Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis about?

Forsythoside A is the main active ingredient in the Chinese medicine Forsythia suspensa, which has antiviral, anti-inflammatory, antioxidation, and immunoregulatory effects. It is reported that Forsythoside A can significantly inhibit the replication of the avian infectious bronchitis virus(IBV) in cells, but there is no report in chickens. The present study aimed to investigate the effect of Forsythoside A on IBV-M41, experiments were designed using 120 chickens at 12 days of age. The chickens were randomly divided into eight groups: Forsythoside A high-, medium-, and low-dose prevention groups, Forsythoside A high-, medium-, and low-dose treatment groups, model control group and normal control group. All chickens, except the normal control group, were inoculated with 0.2 ml of IBV-M41 at 15 days of age.The antiviral effects were evaluated by clinical signs, weight, histopathology, T-,B-lymphocyte proliferation, T-lymphocyte subsets and cytokine levels.The results showed that the infection rate in each Forsythoside A prevention group was significantly lower than that in the treatment group and model control group (P < 0.05). The recovery rate in each Forsythoside A treatment group

Author

Xuebing Wang; Xiao Li; Xuefang Wang; Ling Chen; Erjuan Ning; Yi Fan; Hao Wang; Tong Chen; Wei Wang

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0034-5288)

Published

2020

Language

EN