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This study investigates the in vitro inhibitory effects of Mukuzani wine on pancreatic lipase (PL) and characterizes its kinetic behavior. The findings reveal that the wine exhibits mixed-mode inhibition, with a higher Km and lower Vmax compared to non-inhibited PL, indicating a decrease in PL activity and substrate affinity. Additionally, the phenolic compounds in the wine show uncompetitive inhibition, suggesting potential applications in body weight management.

Author

ლევან გულუა

Language

EN