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Expansion and collapse of VEGF diversity in major clades of the animal kingdom by Khushbu Rauniyar; Honey Bokharaie; Michael Jeltsch is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Expansion and collapse of VEGF diversity in major clades of the animal kingdom about?

Together with the platelet-derived growth factors (PDGFs), the vascular endothelial growth factors (VEGFs) form the PDGF/VEGF subgroup among cystine knot growth factors. The evolutionary relationships within this subgroup have not been examined thoroughly to date. Here, we comprehensively analyze the PDGF/VEGF growth factors throughout all animal phyla and propose a phylogenetic tree. Vertebrate whole-genome duplications play a role in expanding PDGF/VEGF diversity, but several limited duplications are necessary to account for the temporal pattern of emergence. The phylogenetically oldest PDGF/VEGF-like growth factor likely featured a C-terminus with a BR3P signature, a hallmark of the modern-day lymphangiogenic growth factors VEGF-C and VEGF-D. Some younger VEGF genes, such as __VEGFB__ and __PGF__, appeared completely absent in important vertebrate clades such as birds and amphibia, respectively. In contrast, individual PDGF/VEGF gene duplications frequently occurred in fish on top of the known fish-specific whole-genome duplications. The lack of precise counterparts for human genes poses limitations but also offers opportunities for research using organisms that diverge consider

Who reads Expansion and collapse of VEGF diversity in major clades of the animal kingdom?

Author

Khushbu Rauniyar; Honey Bokharaie; Michael Jeltsch

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)