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Thrombin generation assay as a biomarker of cardiovascular outcomes and mortality: A narrative review by Letícia Gonçalves Resende Ferreira; Roberta Carvalho Figueiredo; Maria das Graças Carvalho; Danyelle Romana Alves Rios is a scholarly article available to read on EtoBox.

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Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide. Therefore, there is interest in the search for cardiovascular risk markers that contribute to the early diagnosis, monitoring and prevention of cardiovascular events. Considering that CVDs present in their pathophysiology a strong interaction between inflammation and hemostasis, thrombin, a key enzyme in the clotting process can be thought as a possible biomarker of cardiovascular risk. The thrombin generation assay (TGA) by the Calibrated Automated Thrombogram (CAT) method has been used in numerous prospective studies. It is a relatively recent laboratory tool capable of globally evaluating the functioning of the hemostatic system through the determination of thrombin generation for investigating the contribution of procoagulants and natural anticoagulants, in addition to the effect of different drugs and a range of factors that interfere in this system. The analysis of thrombin generation can be a promising tool for estimating the risk of thrombotic diseases, although the association of TGA with arterial thrombosis has only recently attracted interest and remains to be better understood. The associ

Author

Letícia Gonçalves Resende Ferreira; Roberta Carvalho Figueiredo; Maria das Graças Carvalho; Danyelle Romana Alves Rios

Publisher

Elsevier BV

Published

2022

Language

EN