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Increased expression of matrix metalloproteinase-1 in osteocytes precedes bone resorption as stimulated by disuse: Evidence for autoregulation of the cell's mechanical environment? by Clinton Rubin; Yan-Qun Sun; Michael Hadjiargyrou; Kenneth McLeod is a Medicine article available to read on EtoBox.

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## Abstract An __in vivo__ animal model of bone adaptation was used to examine a possible role for matrix metalloproteinase‐1 in the local mediation of bone remodeling: to corrode the coupling of osteocytes to the matrix in an attempt to autoregulate the cell's perception of its mechanical environment. Twelve young (12–16 months old) skeletally mature turkeys were separated into groups to be studied for stimulus periods of either 3 or 30 days. In each animal, the left ulna was functionally isolated and subjected to either disuse or 3,000 microstrain at 1 Hz for 10 minutes per day. The right ulna remained intact and served as an intra‐animal control. No significant differences in bone area were detected at 3 days; however, ulnae subjected to disuse lost 8 ± 4% (±SD) of bone area by 30 days. Over the same period, ulnae subjected to the mechanical stimulus gained 21 ± 9% of bone area. With use of __in situ__ reverse transcription‐polymerase chain reaction, less than 2% of the osteocytes examined from the intact control ulnae stained positively for matrix metalloproteinase‐1 mRNA. An antibody raised against matrix metalloproteinase‐1 revealed no positively labeled osteocytes in the int

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Author

Clinton Rubin; Yan-Qun Sun; Michael Hadjiargyrou; Kenneth McLeod

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

1999

Language

EN

Field

Medicine (Health Sciences)