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This study identifies para-tyramine-O-sulphate (pTOS) as a significant postprandial metabolite that increases over 1,000-fold in Burmese pythons after feeding. The research demonstrates that pTOS production is microbiome-dependent and activates neural pathways linked to appetite regulation in both pythons and mice. Additionally, pTOS levels are also elevated in human blood post-meal, suggesting a conserved mechanism linking nutrient intake to energy balance across species.

Author

jin2

Language

EN