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What is L-Selectin Binding with Sulfated Lex Sequences about?
The study investigates the binding interactions of L-selectin, a cell adhesion molecule, with various mono- and multisulfated Lewisx oligosaccharides. It finds that 3*-sulfation enhances binding, while 6*-sulfation suppresses it, with 39-sulfated forms showing stronger inhibitory activity compared to sialylated forms. The results suggest that synthetic strategies for therapeutic oligosaccharide analogs should focus on 3*-sulfo-Lex and 3*-sulfo-Lea due to their potent binding properties.
- Author
- balinsoares
- Language
- EN