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Simple Sequential Model for the Kinetics of Conformational Transitions of Oligomeric Helices and Proteins by Elliot L. Elson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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A simple sequential model is developed which is applicable to the kinetics of melting of some types of oligomeric helices and as an idealization to the kinetics of unfolding of some protein molecules. A procedure is presented for calculating the concentrations of all conformational species as functions of time. The time course of experimentally observable quantities which depend on these concentrations may then be computed. One of the most characteristic features of the model is the distinction between a transient and a steady-state phase. During the latter all molecular parameters change a t the same rate, which depends strongly on the difficulty of nucleation and the length of the sequence. Simple approximations to the steady-state rate are discussed in terms of the exact solution. Rates of transient processes depend less strongly on the rate of nucleation and the number of steps and are a more direct reflection of the rates of the elementary process of propagation. The value of experimental observation of transient process is emphasized. @ 1972 by John Wiley I % Sons, Inc. ## 1499 \* When applied to block copolymer helices the successive steps of the model refer to the melting o

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Author

Elliot L. Elson

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1972

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)