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The Maternal-to-Zygotic Transition in C. elegans by Scott Robertson; Rueyling Lin is a nonfiction available to read on EtoBox.

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In Caenorhabditis elegans, the first zygotic transcription can be detected in the 4-cell stage C. elegans embryo, a little over 2h after fertilization. However, early development until the onset of gastrulation at approximately the 28-cell stage takes place normally even in the absence of zygotic transcription. Therefore, posttranslational and posttranscriptional regulation of the maternal proteins and mRNAs, respectively, that are loaded into the developing oocytes is sufficient to direct development prior to gastrulation. Protein phosphorylation is extensively used throughout the C. elegans maternal-to-zygotic transition (MZT): (1) for maternal protein activation, (2) for coordination of the meiotic and mitotic cell cycle, (3) to mark specific proteins for degradation, and/or (4) to switch the biochemical activity of specific proteins. Maternally loaded mRNAs are regulated primarily by a set of maternal RNA-binding proteins (RBPs), each of which binds to sometimes overlapping target sequences within the mRNA 3'UTRs and either promotes or inhibits translation. Most maternal transcripts are uniformly distributed throughout the embryo but specific transcripts are translated only in

Who reads The Maternal-to-Zygotic Transition in C. elegans?

Author

Scott Robertson; Rueyling Lin

Publisher

Academic Press [Imprint] Elsevier Science & Technology Books

Published

2015

Language

EN

ISBN

9780124095236

Category

nonfiction

Subjects

Science, Stem