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The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis by Jing Ye; Yuan Wang; Zhen Wang; Ling Liu; Zicong Yang; Menglong Wang; Yao Xu; Di Ye; Jishou Zhang; Qi Zhou; Yingzhong Lin; Qingwei Ji; Jun Wan is a Immunology and Microbiology article available to read on EtoBox.
What is The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis about?
## Background The interleukin-12 (IL-12) family consists of four members, namely, IL-12, IL-23, IL-27, and IL-35. The aim of this study was to examine the expression of circulating IL-12, IL-23, IL-27, and IL-35 in hypertensive patients. ## Methods Blood samples were collected from hypertensive patients and nonhypertensive (control) subjects, and protein multifactorial monitor kits were used to measure the plasma IL-12, IL-23, IL-27, and IL-35 levels in each sample. In addition, all enrolled subjects underwent ambulatory blood pressure monitoring (ABPM) and vascular stiffness. ## Results Hypertensive patients exhibited higher IL-12, IL-23, and IL-27 levels and lower IL-35 levels than control subjects; IL-12, IL-23, and IL-27 levels were positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP), while IL-35 levels were negatively correlated with SBP and DBP. IL-12, IL-23, and IL-27 levels gradually increased in patients with grade I, II, and III hypertension, while IL-35 levels gradually reduced. According to the ABPM results, hypertensive patients were divided into the dipper and nondipper hypertension groups; IL-12, IL-23, IL-27, and IL-35 le
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- Author
- Jing Ye; Yuan Wang; Zhen Wang; Ling Liu; Zicong Yang; Menglong Wang; Yao Xu; Di Ye; Jishou Zhang; Qi Zhou; Yingzhong Lin; Qingwei Ji; Jun Wan
- Publisher
- Hindawi Publishing Corporation; Hindawi Limited; Abingdon: Carfax; [Cairo]: Hindawi Pub. Corp.; London: Hindawi (ISSN 0962-9351)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)