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Tobacco smoking and chewing, alcohol drinking and lung cancer risk among men in southern India by Vendhan Gajalakshmi; Rayjean J. Hung; Aleyamma Mathew; Cherian Varghese; Paul Brennan; Paolo Boffetta is a Medicine article available to read on EtoBox.

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## Abstract In India, lung cancer is one of the most common and lethal cancers, and tobacco smoking remains its most important etiologic factors. The objective of our study is to examine the effects of different tobacco consumption forms, including smoking and chewing, on lung cancer risk of men in southern India, especially to compare the effects of __bidi__ smoking to cigarette smoking on lung carcinogenesis. We also evaluated the possible role of Indian alcohol beverages and non‐Indian alcohol beverages on lung carcinogenesis. We conducted a case‐control study in Chennai and Trivandrum. In total, 778 lung cancer cases and 3,430 controls, including 1,503 cancer controls and 1,927 healthy controls, were recruited. The effects of cigarette, __bidi__ smoking, chewing and alcohol drinking on the risk of lung cancer were estimated from unconditional multivariate logistic regression. We also applied the generalized additive model (GAM) with locally‐weighted running‐line smoothers (__loess__) to find the most plausible curve for the dose‐response relationship. The results from GAM suggest a plateau after 35 years of smoking or 10 cigarette‐equivalent pack‐years for both cigarette and __

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Author
Vendhan Gajalakshmi; Rayjean J. Hung; Aleyamma Mathew; Cherian Varghese; Paul Brennan; Paolo Boffetta
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
Published
2003
Language
EN
Field
Medicine (Health Sciences)

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