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Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies by Nogueira, Andressa V. B.; Nokhbehsaim, Marjan; Tekin, Sema; de Molon, Rafael S.; Spolidorio, Luis C.; Memmert, Svenja; Damanaki, Anna; Jäger, Andreas; Eick, Sigrun; Deschner, James; Cirelli, Joni A. is a scholarly article available to read on EtoBox.

What is Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies about?

Resistin, a proinflammatory adipokine, is elevated in many inflammatory diseases. However, little is known about its performance in periodontitis. The present study is aimed at evaluating resistin expression and synthesis in periodontal cells and tissues under inflammatory/microbial stress in addition to its effects on the periodontium. In vivo, 24 male rats were randomly divided into two groups: control and ligature-induced periodontal disease. After 6 and 12 days, animals were sacrificed to analyze gene expression of adipokines, bone loss, inflammation, and resistin synthesis. In vitro, human periodontal ligament (PDL) fibroblasts were used to evaluate the expression of resistin after inflammatory stimuli. In addition, PDL fibroblasts were exposed to resistin to evaluate its role on soft and hard tissue metabolism markers. The periodontitis group demonstrated significant bone loss, an increase in the number of inflammatory cells and vascular structures, an increase in resistin expression and synthesis, and a decrease in the expression of adiponectin, leptin, and its functional receptor. PDL fibroblasts showed a significant increase in resistin expression and synthesis in response

Author
Nogueira, Andressa V. B.; Nokhbehsaim, Marjan; Tekin, Sema; de Molon, Rafael S.; Spolidorio, Luis C.; Memmert, Svenja; Damanaki, Anna; Jäger, Andreas; Eick, Sigrun; Deschner, James; Cirelli, Joni A.
Publisher
Hindawi Publishing Corporation; Hindawi Limited; Abingdon: Carfax; [Cairo]: Hindawi Pub. Corp.; London: Hindawi (ISSN 0962-9351)
Published
2020
Language
EN

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