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Use of CytoSorb© Hemoadsorption in Patients on Veno-Venous ECMO Support for Severe Acute Respiratory Distress Syndrome: A Systematic Review by Ali Akil; L. Christian Napp; Cristina Rao; Teresa Klaus; Joerg Scheier; Federico Pappalardo is a scholarly article available to read on EtoBox.

What is Use of CytoSorb© Hemoadsorption in Patients on Veno-Venous ECMO Support for Severe Acute Respiratory Distress Syndrome: A Systematic Review about?

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality. Adjunct hemoadsorption is increasingly utilized to target underlying hyperinflammation derived from ARDS. This article aims to review available data on the use of CytoSorb© therapy in combination with V-V ECMO in severe ARDS, and to assess the effects on inflammatory, laboratory and clinical parameters, as well as on patient outcomes. A systematic literature review was conducted and reported in compliance with principles derived from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. When applicable, a before-and-after analysis for relevant biomarkers and clinical parameters was carried out. CytoSorb© use was associated with significant reductions in circulating levels of C-reactive protein and interleukin-6 ( = 0.039 and = 0.049, respectively). Increases in PaO2/FiO2 reached significance as well ( = 0.028), while norepinephrine dosage reductions showed a non-significant trend ( = 0.067). Mortality rates in CytoSorb© patients tended to be lower than those of control groups of most included studies, which, however, were characterized by high heterogenei

Author

Ali Akil; L. Christian Napp; Cristina Rao; Teresa Klaus; Joerg Scheier; Federico Pappalardo

Published

2022

Language

EN