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Evaluation of Betulinic Acid Effects on Pain, Anxiety, Catalepsy, and Oxidative Stress in Animal Model of Parkinson’s Disease. by Maryam Abrishamdar; Yaghoob Farbood; Alireza Sarkaki; Mohammad Rashno; Mohammad Badavi is a scholarly article available to read on EtoBox.

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## Abstract BackgroundParkinson’s disease (PD) is known by motor impairments. Betulinic acid (BA) is a natural active compound with potent antioxidant activity. The present study addresses the question whether BA affects motor dysfunctions, pain, anxiety and molecular changes in the rat model of PD.MethodsRight medial forebrain bundle (MFB) was lesioned by injection of 6-OHDA in Male Wistar rats. BA (0.5, 5 & 10 mg/kg) and L-dopa (20 mg/kg) were administrated for 7 days. rigidity, anxiety, analgesia and memory, were assessed by bar test, open-field, elevated plus-maze (EPM), tail-flick and shuttle box. Additionally, the malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GPx) activity as well as Brain-derived neurotrophic factor (BDNF) and Interleukin 10 (IL10) levels in the brain tissue were measured.ResultsTreatment with BA significantly reversed the 6-OHDA-induced motor complication in the bar test, but it modified anxiety like behavior neither in open-field nor in EPM, it only decreased the time spent in open arms. Moreover no significant changes were found in the tail-flick between treatment and sham groups. On the other hand, the level of MDA & IL10 wer

Author

Maryam Abrishamdar; Yaghoob Farbood; Alireza Sarkaki; Mohammad Rashno; Mohammad Badavi

Publisher

Research Square Platform LLC

Published

2021

Language

EN