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Photo-mediated Zwitterionic Hydrogel as “Blocked” Platform for Expansion and Maintaining Stemness of Stem Cells by Qingyu Yu; Zhiwei Yue; Chaojie Yu; Lei Liang; Mengmeng Yao; Changhong Chen; Yilan Zhao; Lijie Jiang; Hong Sun; Fanglian Yao; Junjie Li is a Engineering article available to read on EtoBox.
What is Photo-mediated Zwitterionic Hydrogel as “Blocked” Platform for Expansion and Maintaining Stemness of Stem Cells about?
Three-dimensional cell culture based on hydrogels has been a promising method for offering sufficient and effective seed cells for clinical stem cell therapy. However, the development of a required platform is always a great challenge for large expansion and stemness maintenance of stem cells. In this study, a photoresponsive zwitterionic copolymer (PSC)-based hydrogel is designed and prepared, comprising of sulfobetaine methacrylate (SBMA) and coumarin derivative (CMA) segments. By incorporating CMA segments, the PSC hydrogel possesses a comfortable gelation process and rapid photocleavage behavior under different UV radiation for cell encapsulation and harvesting. The SBMA segments provide a clean microenvironment for the stemness maintenance of stem cells via protein resistance. In addition, the cellular recognition peptide CGRGDS immobilized to hydrogel also improves the specific adhesion and proliferative capacity of stem cells. Finally, the well-defined zwitterionic hydrogel can act as a “blocked” platform for cell expansion. Both L929 cells and adipose-derived stem cells (ADSCs) encapsulated in the hydrogel show high viability and expansion. More importantly, zwitterionic hy
Who reads Photo-mediated Zwitterionic Hydrogel as “Blocked” Platform for Expansion and Maintaining Stemness of Stem Cells?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Qingyu Yu; Zhiwei Yue; Chaojie Yu; Lei Liang; Mengmeng Yao; Changhong Chen; Yilan Zhao; Lijie Jiang; Hong Sun; Fanglian Yao; Junjie Li
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)