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Can I read ARID1A ‐deficient cells require HDAC6 for progression of endometrial carcinoma on EtoBox?
ARID1A ‐deficient cells require HDAC6 for progression of endometrial carcinoma by Cristina Megino‐Luque; Pol Sisó; Natalia Mota‐Martorell; Raúl Navaridas; Inés de la Rosa; Izaskun Urdanibia; Manel Albertí‐Valls; Maria Santacana; Miquel Pinyol; Núria Bonifaci; Anna Macià; David Llobet‐Navas; Sònia Gatius; Xavier Matias‐Guiu; Núria Eritja is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is ARID1A ‐deficient cells require HDAC6 for progression of endometrial carcinoma about?
AT‐rich interactive domain‐containing protein 1A (ARID1A) loss‐of‐function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms linking these genetic changes to the altered pathways regulating tumour initiation, maintenance and/or progression remain poorly understood. Thus, the main aim of this study was to analyse the role of ARID1A loss of function in endometrial tumorigenesis. Here, using different endometrial __in vitro__ and __in vivo__ models, such as tumoral cell lines, 3D primary cultures and metastatic or genetically modified mouse models, we show that altered expression of __ARID1A__ is not enough to initiate endometrial tumorigenesis. However, in an established endometrial cancer context, ARID1A loss of function accelerates tumoral progression and metastasis through the disruption of the G2/M cell cycle checkpoint and ATM/ATR‐mediated DNA damage checkpoints, increases epithelial cell proliferation rates and induces epithelial mesenchymal transition through the activation of histone deacetylase 6 (HDAC6). Next, we demonstrated that the inhibition of HDAC6 function, using the HDAC6‐s
Who reads ARID1A ‐deficient cells require HDAC6 for progression of endometrial carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cristina Megino‐Luque; Pol Sisó; Natalia Mota‐Martorell; Raúl Navaridas; Inés de la Rosa; Izaskun Urdanibia; Manel Albertí‐Valls; Maria Santacana; Miquel Pinyol; Núria Bonifaci; Anna Macià; David Llobet‐Navas; Sònia Gatius; Xavier Matias‐Guiu; Núria Eritja
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)