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Hussein et al. investigate the metabolic regulation of a diapause-like state in mouse embryos, revealing that starvation induces a reversible dormant state characterized by mTOR repression and increased glutamine transporter expression. The study identifies unique transcriptional and metabolic signatures associated with this state, including enhanced lipolysis and glycolysis, while highlighting the role of LKB1-AMPK signaling in regulating these processes. These findings provide insights into the molecular
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