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Two Polyene Amides Produced by Genetically Modified Streptomyces diastaticus var. 108 by Elena M. Seco; Trinidad Cuesta; Serge Fotso; Hartmut Laatsch; Francisco Malpartida is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Two Polyene Amides Produced by Genetically Modified Streptomyces diastaticus var. 108 about?

Streptomyces diastaticus var. 108, a newly isolated strain, was recently characterized as a producer of two polyene macrolide antibiotics (rimocidin and CE-108), and the biosynthetic gene cluster was partially characterized. When the producer strain was genetically modified by transformation with some engineered SCP2\*-derived vectors carrying the ermE gene, two previously uncharacterized macrolides were detected in the fermentation broth of the recombinant strain and chemically characterized as the amides of the parental polyene carboxylic acids. The biological activity and some in vitro toxicity assays showed that this chemical modification resulted in pharmaceuticals with improved biological properties compared with the parental products.

Who reads Two Polyene Amides Produced by Genetically Modified Streptomyces diastaticus var. 108?

Author

Elena M. Seco; Trinidad Cuesta; Serge Fotso; Hartmut Laatsch; Francisco Malpartida

Publisher

Elsevier Science; Elsevier ; Cell Press; Elsevier BV (ISSN 1074-5521)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)