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Effects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes by Arthur Ingersen; Malte Schmücker; Christina Alexandersen; Benjamin Graungaard; Tobias Thorngreen; Jacob Borch; Jens Juul Holst; Jørn Wulff Helge; Flemming Dela is a Medicine article available to read on EtoBox.

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## Abstract ## Context Prior to this study, it is known that type 2 diabetes is linked to obesity and a sedentary lifestyle, leading to inadequate β-cell function and insulin resistance. Limited research has explored the metabolic effects of combining exercise training with antidiabetic medications, particularly focusing on insulin secretion in patients with type 2 diabetes and moderately preserved β-cell function. ## Objective The effect of the interaction of semaglutide and physical training on pancreatic β-cell secretory function is unknown in patients with type 2 diabetes. ## Methods Thirty-one patients with type 2 diabetes underwent 12 weeks of aerobic training alone or concurrent to treatment with semaglutide. Patients randomly allocated to concurrent semaglutide and training were treated with semaglutide for 20 weeks before the training and evaluated at inclusion and again before and after the training intervention. Patients randomized to training were evaluated before and after training. The primary outcome was a change in insulin secretory capacity with training, evaluated by a 2-stepped hyperglycemic (20 and 30 mM) clamp. ## Results Training increased the incremental area

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Author

Arthur Ingersen; Malte Schmücker; Christina Alexandersen; Benjamin Graungaard; Tobias Thorngreen; Jacob Borch; Jens Juul Holst; Jørn Wulff Helge; Flemming Dela

Publisher

The Endocrine Society

Published

2023

Language

EN

Field

Medicine (Health Sciences)