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Can I read An Immunologic Portrait of Cancer on EtoBox?
An Immunologic Portrait of Cancer by Libera Maria Ascierto; Valeria De Giorgi; Qiuzhen Liu; Davide Bedognetti; Tara L Spivey; Daniela Murtas; Lorenzo Uccellini; Ben D Ayotte; David F Stroncek; Lotfi Chouchane; Masoud H Manjili; Ena Wang; Francesco M Marincola is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is An Immunologic Portrait of Cancer about?
The advent of high-throughput technology challenges the traditional histopathological classification of cancer, and proposes new taxonomies derived from global transcriptional patterns. Although most of these molecular re-classifications did not endure the test of time, they provided bulk of new information that can reframe our understanding of human cancer biology. Here, we focus on an immunologic interpretation of cancer that segregates oncogenic processes independent from their tissue derivation into at least two categories of which one bears the footprints of immune activation. Several observations describe a cancer phenotype where the expression of interferon stimulated genes and immune effector mechanisms reflect patterns commonly observed during the inflammatory response against pathogens, which leads to elimination of infected cells. As these signatures are observed in growing cancers, they are not sufficient to entirely clear the organism of neoplastic cells but they sustain, as in chronic infections, a self-perpetuating inflammatory process. Yet, several studies determined an association between this inflammatory status and a favorable natural history of the disease or a
Who reads An Immunologic Portrait of Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Libera Maria Ascierto; Valeria De Giorgi; Qiuzhen Liu; Davide Bedognetti; Tara L Spivey; Daniela Murtas; Lorenzo Uccellini; Ben D Ayotte; David F Stroncek; Lotfi Chouchane; Masoud H Manjili; Ena Wang; Francesco M Marincola
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1479-5876)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)