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Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients by Chia-Ing Jan; Cheng-Chia Yu; Mien-Chie Hung; Horng-Jyr Harn; Shin Nieh; Herng-Sheng Lee; Mary Ann Lou; Yi-Chen Wu; Chi-Yuan Chen; Chi-Yang Huang; Fei-Na Chen; Jeng-Fan Lo is a Medicine article available to read on EtoBox.
What is Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients about?
## Abstract ErbB2 (HER2/neu) is overexpressed in about 25–30% of breast malignancies, and up‐regulation of ErbB2 in breast cancer patients is associated with poor prognosis. It is known that the carboxyl terminus of heat shock cognate 70 interacting protein (CHIP) efficiently down‐regulates ErbB2 __in vitro__. Human tumourous imaginal disc 1 (Tid1, DnaJa3), a co‐chaperone of heat shock protein 70 (Hsp70), also suppresses ErbB2 expression in breast cancer cell lines. However, the intracellular interactions among Tid1, CHIP, and ErbB2 remain elusive, and the utilization of Tid1 and CHIP as breast cancer biomarkers has never been proposed. Herein, we analysed the expression and correlations among Tid1, CHIP, and ErbB2 in a total of 183 breast cancer histology sections, including 30 fresh tissue specimens, using immunohistochemistry (IHC) and immunoblotting assay. A computerized image analysis system was used for IHC scoring and determining relative immunoblot intensity. The immunohistochemical expression of Tid1 and CHIP were positively correlated with each other but were both inversely correlated to that of ErbB2. Odds ratio analyses showed that lower expression of Tid1 has a relativ
Who reads Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chia-Ing Jan; Cheng-Chia Yu; Mien-Chie Hung; Horng-Jyr Harn; Shin Nieh; Herng-Sheng Lee; Mary Ann Lou; Yi-Chen Wu; Chi-Yuan Chen; Chi-Yang Huang; Fei-Na Chen; Jeng-Fan Lo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)