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Pemphigus Vulgaris with Oral Involvement: Evaluation of Two Different Systemic Corticosteroid Therapeutic Protocols by F Femiano; F Gombos; C Scully is a Medicine article available to read on EtoBox.

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## Abstract **Background** Pemphigus vulgaris is a potentially life‐threatening disease characterized by cutaneous and mucosal blistering. Systemic corticosteroids remain the mainstay of therapy, transforming an invariably fatal disease into one with a mortality that is now less than 10%. Nevertheless, oral lesions are often recalcitrant and corticosteroid therapy can provoke adverse effects. **Objective** To determine whether two different regimens of systemic corticosteroid therapy based on prednisone gave different benefits. **Method** We examined two different regimens of systemic corticosteroid therapy based on prednisone in an open study. Ten patients (group A) were treated with systemic corticosteroids, in a therapeutic protocol made up of orally administered prednisone. Ten matched patients (group B) were treated with systemic corticosteroids alternating a pulse of intravenous betamethasone with orally administered prednisone. **Results and conclusions** The pulse protocol appeared to have some advantages both in a shorter time to resolution of symptoms and oral lesions, and in terms of minor adverse effects.

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Author

F Femiano; F Gombos; C Scully

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 0926-9959)

Published

2002

Language

EN

Field

Medicine (Health Sciences)