Can I read Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats on EtoBox?

Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats by Shanshan Wang; Yun Li; Wenzhi Li; Kun Zhang; Zhengqiang Yuan; Yina Cai; Kuncheng Xu; Jinrong Zhou; Zhiyun Du is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats about?

## Ethno pharmacological relevance: Curcuma longa l is traditionally used as an anti-inflammatory remedy in chinese traditional medicine. curcuma oil (co), a lipophilic fraction from curcuma longa l. has been reported to have anti-proliferative, anti-inflammatory and anti-oxidant activities. however, co has never been investigated for its possible therapeutic effects on benign prostatic hyperplasia (bph). ## Aims of the study: The study is thus to determine the therapeutic effects of curcuma oil on bph and also the possible mechanism (s) of action. ## Materials &methods: A bph-1 cell line and sprague dawley (sd) rats were used to establish bph models in vitro and in vivo, respectively. rats were treated by co (2.4, 7.2 mg/kg/i.g.) and finasteride (5 mg/kg/i.g.), respectively. histological changes were examined by hematoxylin and eosin (h&e) staining. protein expression was analyzed for 5α-reductase (5ar), dihydrotestosterone (dht), interleukin (il)-1β, il-6 and tumor necrosis factor (tnf)-α by elisa. ki-67, caspase-8,-9 and -3 expressions were evaluated via immunohistochemistry (ihc). ## Results: Co effectively induced apoptosis in bph-1 cells. bph was successfully established by a

Who reads Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats?

Author

Shanshan Wang; Yun Li; Wenzhi Li; Kun Zhang; Zhengqiang Yuan; Yina Cai; Kuncheng Xu; Jinrong Zhou; Zhiyun Du

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)