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Two Regions of Homozygous Deletion Clusters at Chromosome Band 9P21 in Human Lung Cancer by Kunihiro Hamada; Takashi Kohno; Mina Takahashi; Masaaki Yamazaki; Hiroyuki Tashiro; Chiyo Sugawara; Susumu Ohwada; Yoshitaka Sekido; John D. Minna; Jun Yokota is a Medicine article available to read on EtoBox.
What is Two Regions of Homozygous Deletion Clusters at Chromosome Band 9P21 in Human Lung Cancer about?
We examined 149 lung cancer cell lines for homozygous deletions using 24 DNA markers, which were mapped and ordered in chromosome band 9p21, to define the target regions for 9p21 deletions in human lung cancer. Homozygous deletions were detected in 39 (26%) cell lines and clustered at 2 independent regions. One was the region containing the p16/CDKN2A tumor suppressor gene, and this region was deleted in 32 (21%) cell lines. The other was the region containing D9S171, which is the locus approximately 3 Mb proximal to the CDKN2A locus. This region, designated as the D9S171 region, was deleted in 18 (12%) cell lines. Seven of the 18 cell lines had identical minimum deletions of a 17,036 bp sequence located 20 kb distal to the D9S171 locus. However, such a deletion was also observed in the corresponding B-lymphoblastoid cell line from 1 of the 7 cell lines and in 5 (16%) of 32 noncancerous tissues, suggesting that the deletion was a genetic polymorphism. By considering this polymorphism, 11 (7%) cell lines still had deletions at the D9S171 region. Two NSCLC cell lines showed deletions at the D9S171 region and retentions of the CDKN2A locus. Furthermore, an NSCLC cell line showed disco
Who reads Two Regions of Homozygous Deletion Clusters at Chromosome Band 9P21 in Human Lung Cancer?
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- Author
- Kunihiro Hamada; Takashi Kohno; Mina Takahashi; Masaaki Yamazaki; Hiroyuki Tashiro; Chiyo Sugawara; Susumu Ohwada; Yoshitaka Sekido; John D. Minna; Jun Yokota
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Life Sciences)