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Signaling mechanisms in red blood cells: A view through the protein phosphorylation and deformability by Neslihan Cilek; Elif Ugurel; Evrim Goksel; Ozlem Yalcin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Signaling mechanisms in red blood cells: A view through the protein phosphorylation and deformability about?

Intracellular signaling mechanisms in red blood cells (RBCs) involve various protein kinases and phosphatases and enable rapid adaptive responses to hypoxia, metabolic requirements, oxidative stress, or shear stress by regulating the physiological properties of the cell. Protein phosphorylation is a ubiquitous mechanism for intracellular signal transduction, volume regulation, and cytoskeletal organization in RBCs. Spectrin-based cytoskeleton connects integral membrane proteins, band 3 and glycophorin C to junctional proteins, ankyrin and Protein 4.1. Phosphorylation leads to a conformational change in the protein structure, weakening the interactions between proteins in the cytoskeletal network that confers a more flexible nature for the RBC membrane. The structural organization of the membrane and the cytoskeleton determines RBC deformability that allows cells to change their ability to deform under shear stress to pass through narrow capillaries. The shear stress sensing mechanisms and oxygenation-deoxygenation transitions regulate cell volume and mechanical properties of the membrane through the activation of iontransporters and specific phosphorylation events mediated by signa

Who reads Signaling mechanisms in red blood cells: A view through the protein phosphorylation and deformability?

Author

Neslihan Cilek; Elif Ugurel; Evrim Goksel; Ozlem Yalcin

Publisher

Wiley

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)