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Efficacy of Low Dose Schedule Pamidronate Infusion in Children with Osteogenesis Imperfecta by E. González; C. Pavía; J. Ros; M. Villaronga; C. Valls; J. Escolá is a Medicine article available to read on EtoBox.

What is Efficacy of Low Dose Schedule Pamidronate Infusion in Children with Osteogenesis Imperfecta about?

Background: Osteogenesis imperfecta (OI) is a rare condition in which bones are abnormally brittle with frequent fractures. A variety of therapeutic agents has been used with low efficacy. In this study, we present three patients treated for 4 years with i.v. Pamidronate. Patients and methods: Three prepubertal patients, aged 9 (M), 9 (F) and 11 (F) years old, with OI, were treated with 30-60 mg i.v. Pamidronate every 6 months over four years. Determinations were made of plasma 1,25dihydroxycholecalciferol, 25-hydroxycholecalciferol, insulin-like growth factor-I (IGF-I) and its transport protein (IGFBP3), osteocalcin, total alkaline phosphatase and its osseous fraction, and parathormone (PTH) at baseline and after every Pamidronate infusion, Densitometry and X-ray of the vertebral column were performed at the same intervals. Results: Significant reductions of number of bone fractures and pain were observed in all patients, despite lack of any modification in biochemical parameters. Lumbar X-ray and densitometry showed a striking improvement by the end of the treatment period. Conclusion: Pamidronate seems to be useful in the treatment of patients with osteogenesis imperfecta.

Who reads Efficacy of Low Dose Schedule Pamidronate Infusion in Children with Osteogenesis Imperfecta?

Author

E. González; C. Pavía; J. Ros; M. Villaronga; C. Valls; J. Escolá

Publisher

Walter de Gruyter GmbH

Published

2001

Language

EN

Field

Medicine (Health Sciences)