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Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial by Laura Carucci; Rita Nocerino; Lorella Paparo; Francesca De Filippis; Serena Coppola; Veronica Giglio; Tommaso Cozzolino; Vincenzo Valentino; Giuseppina Sequino; Giorgio Bedogni; Roberto Russo; Danilo Ercolini; Roberto Berni Canani is a Medicine article available to read on EtoBox.
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## Abstract ## Background Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% of the pediatric population associated with alteration of skin and gut microbiome. Probiotics have been proposed for AD treatment. The ProPAD study aimed to investigate the therapeutic effects of the probiotic __Lacticaseibacillus rhamnosus__ GG (LGG) in children with AD. ## Methods In total, 100 AD patients aged 6–36 months were enrolled in a randomized, double‐blind, controlled trial to receive placebo (Group A) or LGG (1 x 10^10^ CFU/daily) (Group B) for 12 weeks. The primary outcome was the evaluation of the efficacy of LGG supplementation on AD severity comparing the Scoring Atopic Dermatitis (SCORAD) index at baseline (T0) and at 12‐week (T12). A reduction of ≥8.7 points on the SCORAD index was considered as minimum clinically important difference (MCID). The secondary outcomes were the SCORAD index evaluation at 4‐week (T16) after the end of LGG treatment, number of days without rescue medications, changes in Infant Dermatitis Quality Of Life questionnaire (IDQOL), gut microbiome structure and function, and skin microbiome structure. ## Results The rate of subjects ach
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- Author
- Laura Carucci; Rita Nocerino; Lorella Paparo; Francesca De Filippis; Serena Coppola; Veronica Giglio; Tommaso Cozzolino; Vincenzo Valentino; Giuseppina Sequino; Giorgio Bedogni; Roberto Russo; Danilo Ercolini; Roberto Berni Canani
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)