Can I read Conformational properties of the osmium tetraoxide bispyridine ester of 1-methylthymine and a comment on the linearity of the trans OOsO group on EtoBox?

Conformational properties of the osmium tetraoxide bispyridine ester of 1-methylthymine and a comment on the linearity of the trans OOsO group by Thomas J. Kistenmacher; Luigi G. Marzilli; Miriam Rossi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Conformational properties of the osmium tetraoxide bispyridine ester of 1-methylthymine and a comment on the linearity of the trans OOsO group about?

## ABSTEUC'I' The preparation and crystal and molecuhu structure of the osmium tetraoxide bispyridine ester of 1-methyhhymine are reported. The complex crystallizes in the trichnic system, space group Pi, with 4 = 1 l-493( ).4, b = 16\_655(7)A, c = 6.082(2)A, a = 92.07(3)". fl= 90.58 (3)", -y = 71.36(4)", I' = 1102.4 A3, D, = 1.85(l) g cm-3, D, = 1.84 g crr~-~\_ The unit cell contains 2 osmium tetraoxide bispyridine esters of 1-methylthymine, 2 waters of crystahiaation and 1 disordered pyridine of solvation. Intensities for 3814 independent reflections were collected by counter methods. The structure was solved by standard heavy-atom techniques and has been refined by fulkmatris least squares, based on F, to a final R value of 0.065. The osmium complex binds as a cis osmate ester to the C(5)C(6) bond of the methyhfed pyrimidine in a fashion which is expected to be similar to the binding of the complex to thymidine residues in nucleic acids. The conformation of the 1-methylthymine ester is that of a half chair with C(6) showing a substantial deviation, 0.55 A, from the best mean plane of the thymine moiety. The primary coordination sphere about the OS(W) atom is completed by 2 axiaI

Who reads Conformational properties of the osmium tetraoxide bispyridine ester of 1-methylthymine and a comment on the linearity of the trans OOsO group?

Author

Thomas J. Kistenmacher; Luigi G. Marzilli; Miriam Rossi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0006-3061)

Published

1976

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)