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Carbapenem Nonsusceptible Klebsiella pneumoniae in Taiwan: Dissemination and Increasing Resistance of Carbapenemase Producers During 2012–2015 by Chiu, Sheng-Kang; Ma, Ling; Chan, Ming-Chin; Lin, Yi-Tsung; Fung, Chang-Phone; Wu, Tsu-Lan; Chuang, Yin-Ching; Lu, Po-Liang; Wang, Jann-Tay; Lin, Jung-Chung; Yeh, Kuo-Ming is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Carbapenem Nonsusceptible Klebsiella pneumoniae in Taiwan: Dissemination and Increasing Resistance of Carbapenemase Producers During 2012–2015 about?

## Abstract Before 2011, the prevalence rates of carbapenemase-producing __Klebsiella pneumoniae__ (CPKP) among carbapenem nonsusceptible __K__. __pneumoniae__ (CnSKP) isolates were below 10% in Taiwan. The study presents the dissemination and increased antimicrobial resistance of CPKP from January 2012 to August 2015, as shown by Taiwanese multicenter surveillance. Isolates with minimum inhibitory concentrations (MICs) of >1 μg/mL for imipenem or meropenem were collected, screened for various carbapenemase genes by PCR, and tested for antimicrobial susceptibility. Among 1,457 CnSKP isolates, 1,250 were collected from medical centers. The CnSKP prevalence in medical centers increased by 1.7-fold during the study. Among all CnSKP isolates, 457 were CPKP. The CPKP rate among CnSKP increased by 1.5-fold and reached 36.8% in 2015. The CPKP nonsusceptibility rate to aztreonam, fluoroquinolones, and aminoglycosides increased yearly. Six CPKP isolates carried dual carbapenemase genes. Three Ambler classes were identified in 451 isolates with a single carbapenemase: classes A (315 __bla__~KPC-2~, 2 __bla__~KPC-3~, 28 __bla__~KPC-17~, 2 __bla__~KPC-34~), B (26 __bla__~IMP-8~, 2 __bla__~NDM-

Who reads Carbapenem Nonsusceptible Klebsiella pneumoniae in Taiwan: Dissemination and Increasing Resistance of Carbapenemase Producers During 2012–2015?

Author

Chiu, Sheng-Kang; Ma, Ling; Chan, Ming-Chin; Lin, Yi-Tsung; Fung, Chang-Phone; Wu, Tsu-Lan; Chuang, Yin-Ching; Lu, Po-Liang; Wang, Jann-Tay; Lin, Jung-Chung; Yeh, Kuo-Ming

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)