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Expression patterns of intronic microRNAs in Caenorhabditis elegans by Meltem Isik; Hendrik C Korswagen; Eugene Berezikov is a scholarly article available to read on EtoBox.

What is Expression patterns of intronic microRNAs in Caenorhabditis elegans about?

## Abstract ## Background MicroRNAs (miRNA) are an abundant and ubiquitous class of small RNAs that play prominent roles in gene regulation. A significant fraction of miRNA genes reside in the introns of the host genes in the same orientation and are thought to be co-processed from the host gene mRNAs and thus depend on the host gene promoter for their expression. However, several lines of evidence for independent expression of intronic miRNAs exist in the literature but the extent of this independence remains unclear. ## Results We performed a systematic analysis of genomic regions surrounding intronic miRNAs in the nematode __Caenorhabditis elegans__ and found that, in many cases, there are extended intronic sequences immediately upstream of the miRNAs that are well-conserved between the nematodes. We have generated transcriptional green fluorescent protein reporter fusions in transgenic __C. elegans__ lines and demonstrated that, in all seven investigated cases, the conserved sequences show promoter properties and produce specific expression patterns that are different from the host gene expression patterns. The observed expression patterns are corroborated by the published smal

Author

Meltem Isik; Hendrik C Korswagen; Eugene Berezikov

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2010-2013.; Springer Science and Business Media LLC (ISSN 1758-907X)

Published

2010

Language

EN