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Psychoses after an antiepileptic drug administration: Frequency, timing, and duration by Naoto Adachi; Teiichi Onuma; Masaaki Kato; Masanori Sekimoto; Mitsutoshi Okazaki; Koichiro Hara; Ryouhei Ishii; Masumi Ito; Nozomi Akanuma; Peter Fenwick is a Medicine article available to read on EtoBox.

What is Psychoses after an antiepileptic drug administration: Frequency, timing, and duration about?

Objectives: To clarify the pathophysiology of psychoses after the new administration of antiepileptic drugs (AED), we analyzed the annual incidence, timing of development, and duration of episodes. Methods: Psychotic outcomes in the first 6-month period after an AED or non-AED administration in patients with focal epilepsy were exhaustively reviewed in eight Japanese neuropsychiatry institutions. In cases with psychotic episodes, the subtype of psychosis, timing of development, previous history of psychosis, and duration of the episode were evaluated. Results: Between 1981 and 2015, 5018 new drugs (4402 AED and 616 non-AED) were administered to 2067 patients with focal epilepsy. In the first 6-month period, 105 psychotic episodes occurred (81 interictal psychosis [IIP] and 24 postictal psychosis). Furthermore, 55 cases were first episodes and 50 were recurrent episodes. The frequency of psychoses is significantly higher after AED administration (n = 102) compared with non-AED administration (n = 3). Psychosis occurred most frequently in the initial 1-month period after new-AED administration and tended to decrease with increasing time. The estimated annual incidence of all psychose

Who reads Psychoses after an antiepileptic drug administration: Frequency, timing, and duration?

Author

Naoto Adachi; Teiichi Onuma; Masaaki Kato; Masanori Sekimoto; Mitsutoshi Okazaki; Koichiro Hara; Ryouhei Ishii; Masumi Ito; Nozomi Akanuma; Peter Fenwick

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)