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Computational biology — Modeling of primary blast effects on the central nervous system by David F. Moore; Antoine Jérusalem; Michelle Nyein; Ludovic Noels; Michael S. Jaffee; Raul A. Radovitzky is a Neuroscience article available to read on EtoBox.

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## Objectives: Recent military conflicts in iraq and afghanistan have highlighted the wartime effect of traumatic brain injury (tbi). the reason for the prominence of tbi in these particular conflicts as opposed to others is unclear but may result from the increased survivability of blast due to improvements in body armor. in the military context blunt, ballistic and blast effects may all contribute to cns injury, however blast in particular, has been suggested as a primary cause of military tbi. while blast effects on some biological tissues, such as the lung, are documented in terms of injury thresholds, this is not the case for the cns. we hypothesized that using bio-fidelic models, allowing for fluid-solid interaction and basic material properties available in the literature, a blast wave would interact with cns tissue and cause a possible concussive effect. ## Methods: The modeling approach employed for this investigation consisted of a computational framework suitable for simulating coupled fluid-solid dynamic interactions. the model included a complex finite element mesh of the head and intra-cranial contents. the effects of threshold and 50% lethal blast lung injury were co

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Author

David F. Moore; Antoine Jérusalem; Michelle Nyein; Ludovic Noels; Michael S. Jaffee; Raul A. Radovitzky

Publisher

Elsevier BV

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)