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Protective effects of N‐acetyl‐L‐cysteine against acute carbon tetrachloride hepatotoxicity in rats by Yu. Z. Maksimchik; E. A. Lapshina; E. Yu. Sudnikovich; S. V. Zabrodskaya; I. B. Zavodnik is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract In recent years, N‐acetyl‐L‐cysteine (NAC) has been widely investigated as a potentially useful protective and antioxidative agent to be applied in many pathological states. The aim of the present work was further evaluation of the mechanisms of the NAC protective effect under carbon tetrachloride‐induced acute liver injuries in rats. The rat treatment with CCl~4~ (4 g/kg, intragastrically) caused pronounced hepatolysis observed as an increase in blood plasma bilirubin levels and hepatic enzyme activities, which agreed with numerous previous observations. The rat intoxication was accompanied by an enhancement of membrane lipid peroxidation (1.4‐fold) and protein oxidative damage (protein carbonyl group and mixed protein‐glutathione disulphide formations) in the rat liver. The levels of nitric oxide in blood plasma and liver tissue significantly increased (5.3‐ and 1.5‐fold, respectively) as blood plasma triacylglycerols decreased (1.6‐fold). The NAC administration to control and intoxicated animals (three times at doses of 150 mg/kg) elevated low‐molecular‐weight thiols in the liver. The NAC administration under CCl~4~‐induced intoxication prevented oxidative damage of
Who reads Protective effects of N‐acetyl‐L‐cysteine against acute carbon tetrachloride hepatotoxicity in rats?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yu. Z. Maksimchik; E. A. Lapshina; E. Yu. Sudnikovich; S. V. Zabrodskaya; I. B. Zavodnik
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0263-6484)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)